How do wrinkles form? As skin ages, the dermis (or middle layer) loses its collagen and elastin fibers, so the skin begins to look loose and slack. At the same time the skin becomes thinner and loses fat, so it can look less plump and smooth. Factor in the effects of gravity pulling the skin down, and you've got a wrinkle.3
The three main causes of wrinkles are:
See the difference between a fine line, a wrinkle and a skin fold.
3. American Academy of Dermatology: Mature Skin. http://www.aad.org/public/publications/pamphlets/sun_mature.html. Accessed November 12, 2008.
ReFissa 0.05% is a prescription medicine that may reduce fine facial wrinkles and mottled hyperpigmentation in patients who also protect their skin from the sun and wear sunscreen daily. ReFissa does not eliminate wrinkles, repair sun damaged skin or reverse photo-aging. Do not use if you are pregnant, attempting pregnancy, or nursing. Do not use if taking medicines that may increase your sensitivity to sunlight. Use of ReFissa may make your skin more likely to burn from sunlight. ReFissa, early in treatment, may cause redness, itching, burning, stinging and peeling. If you have questions about side effects, contact your physician. If you are uncomfortable, use less medication and decrease the frequency of application. If discomfort is still significant, discontinue use and consult your physician. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1800-FDA-1088. Please see full Prescribing Information and Patient Package Insert. ReFissa is a registered trademark of ZO® Skin Health. © 2021 ZO® Skin Health. All rights reserved.
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